Genoa to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Genova Piazza Principe and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Genoa to Messina train schedule: the first train leaves at 23:53, while the last ride is at 23:53. A Genoa to Messina train cost about 104.0 €. But how long is the train ride from Genoa to Messina? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Genoa to Messina and find low cost tickets starting from 59 €!