Genoa to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Genova Piazza Principe and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Genoa to Niscemi train schedule: the first train leaves at 17:04, while the last ride is at 23:53. A Genoa to Niscemi train cost about 114.05 €. But how long is the train ride from Genoa to Niscemi? Your journey takes about 23 hours on average.