Giussano to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mariano Comense and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Giussano to Niscemi train schedule: the first train leaves at 17:15, while the last ride is at 18:15. A Giussano to Niscemi train cost about 113.85 €. But how long is the train ride from Giussano to Niscemi? Your journey takes about 13 hours on average.