Isernia to Avola trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Avola every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Avola train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Avola train cost about 55.35 €. But how long is the train ride from Isernia to Avola? Your journey takes about 14 hours on average.