To get from Isernia a Casarano by train you can catch one of the 12 trains that everyday travel between Isernia and Lecce, the closest station to the city. For your trip from Isernia to Lecce by train you can choose to leave from one of Isernia main stations: Isernia, Caserta If travelling with Trenitalia, you need to know the Isernia to Lecce train schedule: the first train leaves at 07:27, while the last ride is at 16:43. A Isernia to Lecce train cost about 42.8 €. But how long is the train ride from Isernia to Lecce? Your journey takes about 7 hours on average.