Isernia to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Castelvetrano train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Castelvetrano train cost about 70.15 €. But how long is the train ride from Isernia to Castelvetrano? Your journey takes about 16 hours on average.