Isernia to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Milazzo every about 4 hours on average. If travelling with Trenitalia, you need to know the Isernia to Milazzo train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Milazzo train cost about 56.55 €. But how long is the train ride from Isernia to Milazzo? Your journey takes about 10 hours on average.