Isernia to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Isernia to Palermo. Trains leave from Isernia and arrive at Palermo Notarbartolo every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Palermo train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Palermo train cost about 71.05 €. But how long is the train ride from Isernia to Palermo? Your journey takes about 14 hours on average.