Isernia to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Palermo Notarbartolo every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Palermo train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Palermo train cost about 71.05 €. But how long is the train ride from Isernia to Palermo? Your journey takes about 14 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Isernia to Palermo and find low cost tickets starting from 32 €!