Isernia to Salerno trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Salerno every about 4 hours on average. If travelling with Trenitalia, you need to know the Isernia to Salerno train schedule: the first train leaves at 08:25, while the last ride is at 18:58. A Isernia to Salerno train cost about 9.45 €. But how long is the train ride from Isernia to Salerno? Your journey takes about 3 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Isernia to Salerno and find low cost tickets starting from 10 €!