Isernia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Isernia to Syracuse train schedule: the first train leaves at 07:27, while the last ride is at 18:58. A Isernia to Syracuse train cost about 35.75 €. But how long is the train ride from Isernia to Syracuse? Your journey takes about 14 hours on average.