Isernia to Trieste trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 5 daily rides to get from Isernia to Trieste. Trains leave from Isernia and arrive at Trieste Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Isernia to Trieste train schedule: the first train leaves at 06:45, while the last ride is at 15:13. A Isernia to Trieste train cost about 74.8 €. But how long is the train ride from Isernia to Trieste? Your journey takes about 9 hours on average.