Isernia to Vigevano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Isernia and arrive at Vigevano every about 6 hours on average. If travelling with Trenitalia, you need to know the Isernia to Vigevano train schedule: the first train leaves at 06:45, while the last ride is at 20:34. A Isernia to Vigevano train cost about 66.05 €. But how long is the train ride from Isernia to Vigevano? Your journey takes about 11 hours on average.