La Spezia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from La Spezia Centrale and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the La Spezia to Messina train schedule: the first train leaves at 16:18, while the last ride is at 18:18. A La Spezia to Messina train cost about 118.0 €. But how long is the train ride from La Spezia to Messina? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from La Spezia to Messina and find low cost tickets starting from 59 €!