Lecce to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Lecce and arrive at Palermo Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Lecce to Palermo train schedule: the first train leaves at 22:30, while the last ride is at 22:30. A Lecce to Palermo train cost about 96.5 €. But how long is the train ride from Lecce to Palermo? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Lecce to Palermo and find low cost tickets starting from 79 €!