Lissone to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Lissone-Muggio' and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Lissone to Messina train schedule: the first train leaves at 07:27, while the last ride is at 21:42. A Lissone to Messina train cost about 110.8 €. But how long is the train ride from Lissone to Messina? Your journey takes about 15 hours on average.