Lissone to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Lissone-Muggio' and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Lissone to Syracuse train schedule: the first train leaves at 07:12, while the last ride is at 21:42. A Lissone to Syracuse train cost about 71.5 €. But how long is the train ride from Lissone to Syracuse? Your journey takes about 18 hours on average.