Manduria to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Oria and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Manduria to Messina train schedule: the first train leaves at 08:13, while the last ride is at 08:13. A Manduria to Messina train cost about 59.05 €. But how long is the train ride from Manduria to Messina? Your journey takes about 11 hours on average.