Manduria to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Oria and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Manduria to Syracuse train schedule: the first train leaves at 08:13, while the last ride is at 08:13. A Manduria to Syracuse train cost about 69.05 €. But how long is the train ride from Manduria to Syracuse? Your journey takes about 15 hours on average.