Manfredonia to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Agrigento Bassa every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Agrigento train schedule: the first train leaves at 17:40, while the last ride is at 17:40. A Manfredonia to Agrigento train cost about 121.8 €. But how long is the train ride from Manfredonia to Agrigento? Your journey takes about 20 hours on average.