Manfredonia to Anzio trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Villa Claudia every about 6 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Anzio train schedule: the first train leaves at 06:38, while the last ride is at 17:40. A Manfredonia to Anzio train cost about 53.4 €. But how long is the train ride from Manfredonia to Anzio? Your journey takes about 6 hours on average.