Manfredonia to Cesena trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Cesena every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Cesena train schedule: the first train leaves at 05:53, while the last ride is at 05:53. A Manfredonia to Cesena train cost about 47.3 €. But how long is the train ride from Manfredonia to Cesena? Your journey takes about 6 hours on average.