Manfredonia to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Comiso train schedule: the first train leaves at 06:38, while the last ride is at 20:40. A Manfredonia to Comiso train cost about 73.45 €. But how long is the train ride from Manfredonia to Comiso? Your journey takes about 9 hours on average.