Manfredonia to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Enna every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Enna train schedule: the first train leaves at 17:40, while the last ride is at 17:40. A Manfredonia to Enna train cost about 105.15 €. But how long is the train ride from Manfredonia to Enna? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Manfredonia to Enna and find low cost tickets starting from 71 €!