Manfredonia to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Enna every about 12 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Enna train schedule: the first train leaves at 17:40, while the last ride is at 17:40. A Manfredonia to Enna train cost about 105.15 €. But how long is the train ride from Manfredonia to Enna? Your journey takes about 17 hours on average.