Manfredonia to Messina trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Manfredonia to Messina. The first train to Messina leaves from Manfredonia at 05:53 and the last train departs at 05:53. If you choose a local train the trip lasts on average 13:37 hours. For your trip from Manfredonia to Messina by train you can choose to leave from one of Manfredonia main stations: Manfredonia On Wanderio you can compare all schedules, fares and railway companies to Messina and book the best itinerary starting from Manfredonia.