Manfredonia to Noto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Noto every about 3 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Noto train schedule: the first train leaves at 06:38, while the last ride is at 20:40. A Manfredonia to Noto train cost about 70.45 €. But how long is the train ride from Manfredonia to Noto? Your journey takes about 16 hours on average.