Manfredonia to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Palermo Notarbartolo every about 6 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Palermo train schedule: the first train leaves at 17:40, while the last ride is at 20:40. A Manfredonia to Palermo train cost about 71.5 €. But how long is the train ride from Manfredonia to Palermo? Your journey takes about 20 hours on average.