Manfredonia to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Varese every about 4 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Varese train schedule: the first train leaves at 06:38, while the last ride is at 20:40. A Manfredonia to Varese train cost about 65.6 €. But how long is the train ride from Manfredonia to Varese? Your journey takes about 11 hours on average.