Marsala to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mozia-Birgi and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Marsala to Messina train schedule: the first train leaves at 06:03, while the last ride is at 16:17. A Marsala to Messina train cost about 18.3 €. But how long is the train ride from Marsala to Messina? Your journey takes about 7 hours on average.