Melegnano to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melegnano and arrive at Messina Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Melegnano to Messina train schedule: the first train leaves at 07:38, while the last ride is at 22:20. A Melegnano to Messina train cost about 148.8 €. But how long is the train ride from Melegnano to Messina? Your journey takes about 15 hours on average.