Melegnano to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melegnano and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Melegnano to Niscemi train schedule: the first train leaves at 07:12, while the last ride is at 07:12. A Melegnano to Niscemi train cost about 155.85 €. But how long is the train ride from Melegnano to Niscemi? Your journey takes about 10 hours on average.