Melegnano to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melegnano and arrive at Palermo Notarbartolo every about 4 hours on average. If travelling with Trenitalia, you need to know the Melegnano to Palermo train schedule: the first train leaves at 14:08, while the last ride is at 19:08. A Melegnano to Palermo train cost about 110.1 €. But how long is the train ride from Melegnano to Palermo? Your journey takes about 20 hours on average.