Melzo to Desio trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melzo and arrive at Desio every 20 minutes on average. If travelling with Trenitalia, you need to know the Melzo to Desio train schedule: the first train leaves at 05:35, while the last ride is at 05:35. A Melzo to Desio train cost about 4.0 €. But how long is the train ride from Melzo to Desio? Your journey takes about 1 hour on average.