Melzo to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melzo and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Melzo to Messina train schedule: the first train leaves at 07:44, while the last ride is at 21:28. A Melzo to Messina train cost about 110.8 €. But how long is the train ride from Melzo to Messina? Your journey takes about 14 hours on average.