Melzo to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Melzo to Niscemi. If travelling with Trenitalia, you need to know the Melzo to Niscemi train schedule: the first train leaves at 16:57, while the last ride is at 19:13. A Melzo to Niscemi train cost about 116.65 €. But how long is the train ride from Melzo to Niscemi? Your journey takes about 13 hours on average.