Melzo to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melzo and arrive at Palermo Notarbartolo every about 6 hours on average. If travelling with Trenitalia, you need to know the Melzo to Palermo train schedule: the first train leaves at 16:57, while the last ride is at 19:13. A Melzo to Palermo train cost about 110.1 €. But how long is the train ride from Melzo to Palermo? Your journey takes about 20 hours on average.