Melzo to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melzo and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Melzo to Syracuse train schedule: the first train leaves at 07:14, while the last ride is at 21:28. A Melzo to Syracuse train cost about 71.5 €. But how long is the train ride from Melzo to Syracuse? Your journey takes about 18 hours on average.