Mesagne to Agrigento trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Mesagne to Agrigento. Trains leave from Mesagne and arrive at Agrigento Bassa every about 6 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Agrigento train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Agrigento train cost about 79.15 €. But how long is the train ride from Mesagne to Agrigento? Your journey takes about 24 hours on average.