Mesagne to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Alpignano every about 4 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Alpignano train schedule: the first train leaves at 04:38, while the last ride is at 13:10. A Mesagne to Alpignano train cost about 113.75 €. But how long is the train ride from Mesagne to Alpignano? Your journey takes about 15 hours on average.