Mesagne to Ancona trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Ancona every about 2 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Ancona train schedule: the first train leaves at 07:05, while the last ride is at 18:20. A Mesagne to Ancona train cost about 40.0 €. But how long is the train ride from Mesagne to Ancona? Your journey takes about 7 hours on average.