Mesagne to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Castelvetrano every about 4 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Castelvetrano train schedule: the first train leaves at 08:00, while the last ride is at 11:01. A Mesagne to Castelvetrano train cost about 79.8 €. But how long is the train ride from Mesagne to Castelvetrano? Your journey takes about 2 hours on average.