Mesagne to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Comiso train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Comiso train cost about 77.95 €. But how long is the train ride from Mesagne to Comiso? Your journey takes about 5 hours on average.