Mesagne to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Enna every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Enna train schedule: the first train leaves at 20:35, while the last ride is at 20:35. A Mesagne to Enna train cost about 52.95 €. But how long is the train ride from Mesagne to Enna? Your journey takes about 23 hours on average.