Mesagne to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Niscemi train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Niscemi train cost about 73.8 €. But how long is the train ride from Mesagne to Niscemi? Your journey takes 17 minutes on average.