Mesagne to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Mesagne to Niscemi. Trains leave from Mesagne and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Niscemi train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Niscemi train cost about 73.8 €. But how long is the train ride from Mesagne to Niscemi? Your journey takes 17 minutes on average.