Mesagne to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Palermo Notarbartolo every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Palermo train schedule: the first train leaves at 20:35, while the last ride is at 20:35. A Mesagne to Palermo train cost about 60.1 €. But how long is the train ride from Mesagne to Palermo? Your journey takes about 23 hours on average.