Mesagne to Trapani trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Trapani every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Trapani train schedule: the first train leaves at 09:50, while the last ride is at 09:50. A Mesagne to Trapani train cost about 130.9 €. But how long is the train ride from Mesagne to Trapani? Your journey takes about 4 hours on average.