Messina to Avezzano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Avezzano every about 2 hours on average. If travelling with Trenitalia, you need to know the Messina to Avezzano train schedule: the first train leaves at 00:35, while the last ride is at 22:10. A Messina to Avezzano train cost about 45.9 €. But how long is the train ride from Messina to Avezzano? Your journey takes about 12 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Avezzano and find low cost tickets starting from 19 €!