Messina to Casalnuovo di Napoli trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Casalnuovo di Napoli every about 4 hours on average. If travelling with Trenitalia, you need to know the Messina to Casalnuovo di Napoli train schedule: the first train leaves at 00:35, while the last ride is at 00:35. A Messina to Casalnuovo di Napoli train cost about 51.0 €. But how long is the train ride from Messina to Casalnuovo di Napoli? Your journey takes about 7 hours on average.