Messina to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Messina to Castelvetrano train schedule: the first train leaves at 14:23, while the last ride is at 14:23. A Messina to Castelvetrano train cost about 16.1 €. But how long is the train ride from Messina to Castelvetrano? Your journey takes about 6 hours on average.