Messina to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Mozia-Birgi every about 6 hours on average. If travelling with Trenitalia, you need to know the Messina to Marsala train schedule: the first train leaves at 06:45, while the last ride is at 14:23. A Messina to Marsala train cost about 18.3 €. But how long is the train ride from Messina to Marsala? Your journey takes about 9 hours on average.