Messina to Rome trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Roma Termini every about 12 hours on average. If travelling with Trenitalia, you need to know the Messina to Rome train schedule: the first train leaves at 22:10, while the last ride is at 22:10. A Messina to Rome train cost about 44.90 €. But how long is the train ride from Messina to Rome? Your journey takes about 9 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Messina to Rome and find low cost tickets starting from 12 €! If you need to travel this week, prices range from 87.50 € to 87.50€. Booking your train ticket a few weeks in advance though, you can find low cost trains from Messina to Rome with fares starting from 44.90€, saving 48% on average.